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The Stanford Center for Clinical Research

A Nexus for Team Science

August 16, 2024  Team science and collaborative research are increasingly required to generate evidence that advances clinical care. The design and conduct of these large studies with numerous collaborators can present significant challenges. The Stanford Center for Clinical Research (SCCR) offers the expertise and infrastructure necessary to successfully launch and coordinate research that brings together a diverse group of physicians, scientists, research staff, and health care professionals. Through partnership with internal and external collaborators, SCCR provides operational support for site-based clinical research and clinical coordination of multi-center studies.  

“I fundamentally believe that team science is critical to answer important complex clinical questions. The synergies of collaboration by physicians from diverse therapeutic areas, data scientists, and operation teams create the foundation for rigorous study design, innovative operations, and data quality,” said Kenneth Mahaffey, MD, professor of cardiovascular medicine and director of SCCR.

An exemplary team science project at SCCR is the Cellular Immune Tolerance Research Program (CIT). CIT unites faculty from BMT, radiation oncology, endocrinology, abdominal transplant, rheumatology, nephrology, and neurology. Their shared mission is to develop innovative cellular immune therapy treatments for patients with autoimmune diseases and those undergoing transplantation. CIT is a coordinated effort to assist investigators across Stanford Medicine with operational and compliance support while also serving as a knowledge-integration hub.

SCCR is at the forefront of the REACT-AF study, a multi-center trial comparing standard anticoagulation in individuals with AFib to targeted intermittent anticoagulation guided by an AF-sensing smartwatch. SCCR leads the clinical coordinating center for this nation-wide, 100-site study. The REACT-AF trial represents the quintessence of academic and inter-institutional collaboration, bringing together faculty from Stanford University, Johns Hopkins University, University of California, San Francisco, and Northwestern University. 

A key strength of SCCR is the breadth of its clinical and operational teams that closely collaborate with faculty. Their expertise spans project management, site management, education and training, quality, compliance, finance and administration.

Additionally, division leaders, research coordinators, clinical and non-clinical managers, nurses, and social workers all work together through SCCR to ensure participant safety and the seamless integration of research into clinical throughput. In addition, SCCR works with institution-wide groups such as Stanford Research Management Group, Stanford Privacy Office, and the data science teams such as the Quantitative Science Unit and the Stanford Center for Innovative Design to ensure an efficient study startup process.

"Team science is critical to answer important complex clinical questions. The collaboration of diverse physicians creates the foundation for rigorous study design." - Kenneth Mahaffey, MD, SCCR Director

SCCR engages with a wide range of partners to meet a diverse set of clinical research needs. Whether it is executing a trial, partnering in new ventures, training internal and external teams, or by monitoring trials, SCCR is committed to collaborating to meet clinical research needs. Visit their newly launched website to learn how your team can partner with SCCR .

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The Stanford Autoimmune & Allergy Supergroup (SAAS) connects researchers across departments and disciplines

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Institutes at nih, list of institutes and centers, nih institutes.

National Cancer Institute (NCI) — Est. 1937 NCI leads a national effort to eliminate the suffering and death due to cancer. Through basic and clinical biomedical research and training, NCI conducts and supports research that will lead to a future in which we can prevent cancer before it starts, identify cancers that do develop at the earliest stage, eliminate cancers through innovative treatment interventions, and biologically control those cancers that we cannot eliminate so they become manageable, chronic diseases.

National Eye Institute (NEI) — Est. 1968 The National Eye Institute’s mission is to conduct and support research, training, health information dissemination, and other programs with respect to blinding eye diseases, visual disorders, mechanisms of visual function, preservation of sight, and the special health problems and requirements of the blind.

National Heart, Lung, and Blood Institute (NHLBI) — Est. 1948 The National Heart, Lung, and Blood Institute (NHLBI) provides global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives. The NHLBI stimulates basic discoveries about the causes of disease, enables the translation of basic discoveries into clinical practice, fosters training and mentoring of emerging scientists and physicians, and communicates research advances to the public.

National Human Genome Research Institute (NHGRI) — Est. 1989 NHGRI is devoted to advancing health through genome research. The Institute led NIH’s contribution to the Human Genome Project, which was successfully completed in 2003 ahead of schedule and under budget. Building on the foundation laid by the sequencing of the human genome, NHGRI’s work now encompasses a broad range of research aimed at expanding understanding of human biology and improving human health. In addition, a critical part of NHGRI’s mission continues to be the study of the ethical, legal and social implications of genome research.

National Institute on Aging (NIA) — Est. 1974 NIA leads a national program of research on the biomedical, social, and behavioral aspects of the aging process; the prevention of age-related diseases and disabilities; and the promotion of a better quality of life for all older Americans.

National Institute on Alcohol Abuse and Alcoholism (NIAAA) — Est. 1970 NIAAA conducts research focused on improving the treatment and prevention of alcoholism and alcohol-related problems to reduce the enormous health, social, and economic consequences of this disease.

National Institute of Allergy and Infectious Diseases (NIAID) — Est. 1948 NIAID research strives to understand, treat, and ultimately prevent the myriad infectious, immunologic, and allergic diseases that threaten millions of human lives.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) — Est. 1986 NIAMS supports research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases.

National Institute of Biomedical Imaging and Bioengineering (NIBIB) — Est. 2000 The mission of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) is to transform through engineering the understanding of disease and its prevention, detection, diagnosis, and treatment.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) — Est. 1962 NICHD leads research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all.

National Institute on Deafness and Other Communication Disorders (NIDCD) — Est. 1988 NIDCD conducts and supports biomedical research and research training on normal mechanisms as well as diseases and disorders of hearing, balance, smell, taste, voice, speech, and language that affect 46 million Americans.

National Institute of Dental and Craniofacial Research (NIDCR) — Est. 1948 NIDCR provides leadership for a national research program designed to understand, treat, and ultimately prevent the infectious and inherited craniofacial-oral-dental diseases and disorders that compromise millions of human lives.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) — Est. 1950 The mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is to conduct and support medical research and research training and to disseminate science-based information on diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases, to improve people’s health and quality of life.

National Institute on Drug Abuse (NIDA) — Est. 1974 The mission of the National Institute on Drug Abuse (NIDA) is to advance science on the causes and consequences of drug use and addiction and to apply that knowledge to improve individual and public health. 

National Institute of Environmental Health Sciences (NIEHS) — Est. 1969 The mission of the National Institute of Environmental Health Sciences is to discover how the environment affects people in order to promote healthier lives.

National Institute of General Medical Sciences (NIGMS) — Est. 1962 The National Institute of General Medical Sciences (NIGMS) supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment and prevention. NIGMS-funded scientists investigate how living systems work at a range of levels, from molecules and cells to tissues, whole organisms and populations. The Institute also supports research in certain clinical areas, primarily those that affect multiple organ systems. To assure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacities throughout the country.

National Institute of Mental Health (NIMH) — Est. 1949 NIMH provides national leadership dedicated to understanding, treating, and preventing mental illnesses through basic research on the brain and behavior, and through clinical, epidemiological, and services research.

National Institute on Minority Health and Health Disparities (NIMHD) — Est. 2010 NIMHD has a long history, beginning in 1990 as an Office and later designated a Center in 2000. The mission of NIMHD is to lead scientific research to improve minority health and eliminate health disparities. To accomplish its mission, NIMHD plans, reviews, coordinates, and evaluates all minority health and health disparities research and activities of the National Institutes of Health; conducts and supports research in minority health and health disparities; promotes and supports the training of a diverse research workforce; translates and disseminates research information; and fosters innovative collaborations and partnerships.

National Institute of Neurological Disorders and Stroke (NINDS) — Est. 1950 The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. To accomplish this goal the NINDS supports and conducts basic, translational, and clinical research on the normal and diseased nervous system. The Institute also fosters the training of investigators in the basic and clinical neurosciences, and seeks better understanding, diagnosis, treatment, and prevention of neurological disorders.

National Institute of Nursing Research (NINR) — Est. 1986 The mission of the National Institute of Nursing Research (NINR) is to lead nursing research to solve pressing health challenges and inform practice and policy—optimizing health and advancing health equity into the future.

National Library of Medicine (NLM) — Est. 1956 NLM collects, organizes, and makes available biomedical science information to scientists, health professionals, and the public. The Library’s Web-based databases, including PubMed/Medline and MedlinePlus, are used extensively around the world. NLM conducts and supports research in biomedical communications; creates information resources for molecular biology, biotechnology, toxicology, and environmental health; and provides grant and contract support for training, medical library resources, and biomedical informatics and communications research.

NIH Centers

NIH Clinical Center (CC) — Est. 1953 The NIH Clinical Center, America’s research hospital, provides a versatile clinical research environment enabling the NIH mission to improve human health by investigating the pathogenesis of disease; conducting first-in-human clinical trials with an emphasis on rare diseases and diseases of high public health impact; developing state-of-the-art diagnostic, preventive, and therapeutic interventions; training the current and next generations of clinical researchers; and, ensuring that clinical research is ethical, efficient, and of high scientific quality.

Center for Information Technology (CIT) — Est. 1964 CIT incorporates the power of modern computers into the biomedical programs and administrative procedures of the NIH by focusing on three primary activities: conducting computational biosciences research, developing computer systems, and providing computer facilities.

Center for Scientific Review (CSR) — Est. 1946 CSR is the portal for NIH grant applications and their review for scientific merit. CSR oversees and implements peer review for over 75% of the more than 88,000 applications submitted to NIH each year, as well as for some other components of HHS. The mission of CSR is to see that NIH grant applications receive fair, independent, expert, and timely scientific reviews — free from inappropriate influences — so NIH can fund the most promising research.

Fogarty International Center (FIC) — Est. 1968 FIC promotes and supports scientific research and training internationally to reduce disparities in global health.

National Center for Advancing Translational Sciences (NCATS) — Est. 2011 The mission of NCATS is to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.

National Center for Complementary and Integrative Health (NCCIH) — Est. 1999 The mission of NCCIH is to define, through rigorous scientific investigation, the usefulness and safety of complementary and integrative health interventions and their roles in improving health and health care.

This page last reviewed on July 12, 2023

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