President and CEO, Dana-Farber Cancer Institute
Director of Dana-Farber Harvard Cancer Center, CEO, Dana-Farber/Partner CancerCare
Richard and Susan Smith Professor of Medicine, Professor of Pediatrics, Professor of Pathology,
Harvard Medical School, Boston, MA
Q: How did you become interested in the field of hematology? Academia in particular?
A: I became interested in academic medicine before becoming interested in hematology. It started in high school when I got in an argument with a nun about how many chromosomes man has. That got me interested in DNA and then molecular biology (MB). I was very interested in MB research in college and wanted to pursue patient research in MB, which was very new in the 70s. I became interested in hematology because of a presentation by David Nathan (a past president of the American Society of Hematology). I realized hematology was the only field that would allow me to use MB research to study human disease. It was virtually impossible in other areas, except in hematology because you can work directly with patient blood cells.
Q: Why do you think it is important for people to get involved in this field?
A: Because hematologists are responsible for treating patients with many major conditions that cause illness and death. For example, one third of patients with cancer actually die of blood-clotting related to their cancer. Also, it is still the specialty of medicine where the newest discoveries in science first get applied to human disease.
Q: In your experience, what is the most difficult or challenging aspect of becoming a hematologist in the United States?
A: It's not that challenging to become one - you have to go to medical school, get into a good residency program, then be accepted into a fellowship - those hurdles are true for every specialty in medicine. The challenge in being a hematologist, unless you're also an oncologist, is the reimbursement scheme, which makes it difficult to be in private practice in hematology. If you're interested in working purely in hematology, you will find yourself working at an academic center. If you want to work in private practice by being a hematologist/oncologist, the oncology part of your practice will overwhelm hematology and make it hard for you to focus on hematology and keep up with the research.
Hematology is a broad discipline so you have to master many different subtopics of hematology - for example, in leukemia, bone marrow failure, transfusion medicine, etc. So, you have to be able to think broadly as well as deeply.
Q: How do you feel advances in technology (recent or past) have helped you along the way, be it in your studies or in general practice?
A: Advances in scientific technology have been incredibly helpful for diagnosis and treatment of hematologic disorders. We can now give growth factors to help patients replace the loss of red and white blood cells who used to need transfusion. We can replace clotting factors in hemophilia. We can diagnose leukemia to a level of precision that we can customize therapies in a more advanced way than most other areas of medicine.
Q: What do you find to be most rewarding about a career in hematology?
A: You can do good because you're taking care of patients and helping them with conditions that really require specialized knowledge. And you can do research that is still on the very cutting edge of science but still very relevant to the needs of your patients. Hematologists are the nicest docs out there.
Q: Finally, what advice might you have for a younger person who will be pursuing a career in this field?
A: You want to be sure that you're achieving academically. You need a very strong background in science, and be sure that you're learning great communication skills so you can be both a physician and a scientist. Hematologists must be adept at all of the things that make you a caring physician but also very well prepared scientifically because it is a science-driven discipline.
The beautiful thing about hematology is that there are so many ways where you can be of use to patients and study something truly fascinating. If you're a good hematologist, you'll have unique knowledge and the ability to help patients that no one else can help, and you can still be a very accomplished researcher.
After my second year of medical school I took a year off to try to apply the brand new techniques of MB to study a form of inherited anemia called thalassemia. I was trying to do something that no one has ever tried to do before. At 49 weeks out of my 52 weeks in the lab, I had nothing - nothing worked. I paid a visit to a professor at the Massachusetts Institute of Technology (across the river), and during the course of that conversation we realized I had the right question to answer, and he had the right system to answer it. In the next three weeks we were able to generate data that really launched my career and today remains one of my most important research contributions. Lesson: You can feel like you're beating your head against the wall, but you're only one conversation away from something really special. I had been contemplating quitting, but my mentor wouldn't let me do it. Find people you feel you can really trust with your future.
Thalassemia patients don't make hemoglogbin. In those days we knew genetic diseases could result in making abnormal proteins that functioned in the wrong way. No one had a way of understanding diseases in which you failed to regulate the protein.
We were the first at the National Institutes of Health to isolate and express human messenger RNA (ribonucleic acid) and show that it was a defect in that messenger RNA in these patients that explained why they had the disease. It was among the first applications of MB to explain human disease. The other lab that deserves credit is the lab of Art Nienhuis who worked with French Anderson. I worked with Bernie Forget - they were our senior mentors.
Research is a long run for a short slide.
Find inspiration from hematologists working in a number of areas by learning more about what interested them in the field, current challenges, and advice for future hematologists.
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Job information, offer description.
Institute of Hematology and Transfusion Medicine in Warsaw, Poland, offers three PhD candidate positions in the project “ Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate immunity and anti-tumor response in diffuse large B-cell lymphoma” , supervised by prof. Przemysław Juszczyński, MD, PhD.
Our group has recently demonstrated that blocking the activity of PIM kinases induces lymphoma cell death, but simultaneously increases the susceptibility of the tumor to the immune system attack (DOI:10.1158/0008-5472.CAN-21-1023). We have recently started to characterize additional immunomodulatory mechanisms associated with PIM kinase inhibition. Since generated inflammatory signals may reshape tumor microenvironment from “cold” to “hot”, which helps the immune system to combat the tumor, we plan to characterize and understand in detail the mechanisms of PIM kinase inhibition-mediated immunomodulation.
Institute of Hematology and Transfusion Medicine is one of the leading research institutions in Poland and a reference hematooncology center. Studies will be performed in a young, dynamic group, providing opportunities for successful publishing of research results. We offer scientific development oportunities, collaboration with leading research institutions nationally and internationally and access to cutting-edge research technologies.
Selected candidates will be enrolled to a do doctoral school. We offer two PhD fellowships ( 5000 PLN ) for the first two years, increased after the interim evaluation (after 2 years).
Requirements.
REQUIRED DOCUMENTS
PLEASE SUBMIT ALL THE REQUIRED DOCUMENTS IN ENGLISH, WITHIN A SINGLE PDF FILE.
The application documents should include the following statement:
„I hereby give consent to process my personal data included in my offer, for the purposes of the recruitment procedure, and to disclose my name and surname in the "recruitment results" section of the IHT website, by the Institute of Hematology and Transfusion Medicine, address: I. Gandhi 14 Str, Warsaw, Poland ; REGON 000849327, NIP 777-00-02-062 (further referred to as the Institute). I acknowledge that the Institute hereby becomes the administrator of my data. I have been acquainted with all the consequences resulting thereof, in particular with the following facts:
1. For more details with regard to processing my personal data, I can contact the Data Protection Officer: [email protected]
2. My personal data are processed for the purposes of the recruitment procedure.
3. Members of the relevant recruitment committees are recipients of my personal data.
4. My personal data shall not be transferred to any Third Party.
5. My personal data will be processed for the period of 28 days upon the date when the recruitment procedure is concluded. Following this period, they will be irretrievably and effectively destroyed, so that they can no longer be accessed or reconstructed by any means.
At the same time, I acknowledge that I have the right to request from the Institute access to my personal data and the right to amend them or withdraw my consent to process them. I also declare that I have been informed about my right to file complaint to the President of the Office for Personal Data Protection, in the case when the Institute breaches the principles of processing my personal data, stipulated in the Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC”.*
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Tian Yi Zhang is an Assistant Professor of Medicine in Hematology and a member of Stanford Cancer Institute. She earned her MD and PhD from University of Utah. Dr. Zhang completed her Hematology and Oncology Fellowship at Stanford and is a board-certified hematologist. While at Stanford, she completed post-doctoral training in the laboratory of ...
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Hedy Smith, MD, PhD, is a hematologist and member of the American Society of Hematology who specializes in the diagnosis and treatment of hemoglobin disorders, including thalassemia and sickle cell disease; bleeding and thrombotic disorders; cytopenias; immune disorders, such as immune thrombocytopenic (or ITP), autoimmune hemolytic anemias, and common variable immune deficiency; and ...
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Dr. Faith is a clinical pediatric psychologist specializing in hematology/oncology at Johns Hopkins All Children's Hospital. She received her master's and doctorate degrees in clinical psychology from the University of Arkansas, completed a predoctoral internship in clinical child psychology at the University of Mississippi Medical Center and completed a postdoctoral fellowship in clinical ...
Edward Benz Jr., MD, PhD: Why I Chose Hematology. American Society of Hematology President - 2000. President and CEO, Dana-Farber Cancer Institute. Director of Dana-Farber Harvard Cancer Center, CEO, Dana-Farber/Partner CancerCare. Richard and Susan Smith Professor of Medicine, Professor of Pediatrics, Professor of Pathology,
Dr. Sara Karjoo, MD. Hematology, Pediatric Gastroenterology, Pediatrics. 1.5. 8 Ratings. 17 Years Experience. 1200 7th Ave N, Saint Petersburg, FL 33705 2.55 miles. Dr. Karjoo graduated from the Suny Upstate Medical University College of Medicine in 2007.
Institute of Hematology and Transfusion Medicine in Warsaw, Poland, offers three PhD candidate positions in the project "Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate immunity and anti-tumor response in diffuse large B-cell lymphoma", supervised by prof. Przemysław Juszczyński, MD, PhD.